drdaviss@psychopharminfo.com
www.psychopharmINFO.com
Newsletter
Number 2
Monday, February 10, 2003
PPI Index: *89.5 (-4.3%)
Copyright 2003 by Steven R. Daviss
The feedback on the newsletter has been quite positive; thank you. I have not yet got the formatting quite right for printing and scrolling the newsletter. To print it, you must indicate Landscape mode in your printer settings. To reduce scrolling left and right onscreen, go to View>TextSize and reduce your font size. I should have this fixed by next issue. Once the formatting is improved, you'll be seeing more original content. For this week, I'll discuss the statistics included at the top of each medication section, and how they can help you keep a pulse on what's happening in the psychopharm market. Thanks, Steve.
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TOP 10 GOOGLE NEWS ANTIDEPRESSANTS
- Prozac 374 hits (1)
- Paxil 184 hits (2)
- Zoloft 85 hits (3)
- Effexor 64 hits (4)
- Strattera 51 hits (5)
- Wellbutrin 36 hits (7)
- Cymbalta 32 hits (6)
- Celexa 18 hits (9)
- Remeron 13 hits (10)
- Serzone 5 hits (8)
(by number of hits; (#)=position last week)
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TOP 10 SEARCHES FOR ANTIDEPRESSANTS
- Lexapro 7754 searches (+3%)
- Paxil 7170 searches (-1%)
- Wellbutrin 5547 searches (-1%)
- Zoloft 5443 searches (-1%)
- Effexor 5358 searches (0)
- Celexa 4818 searches (-4%)
- Prozac 3429 searches (-1%)
- Remeron 1593 searches (0)
- Strattera 1013 searches (+31%)
- Serzone 710 searches (-4%)
(by search hits; %=change from last week, as per WordTracker)
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SIDE EFFECTS & INTERACTIONS
- • Brain development
- -fluoxetine
- • Sleep
- -mirtazapine
- • Restless legs syndrome
- -mirtazapine
- • Sexual
- -paroxetine
- • Vaginal bleeding
- -sertraline
- • Interactions
- -paroxetine-sildenafil/Viagra
Go To: | CELEXA | CYMBALTA | EFFEXOR | LEXAPRO | LUVOX | PAXIL | PROZAC | REMERON | SARAFEM | SERZONE | STRATTERA | WELLBUTRIN | ZOLOFT | ZYBAN |
ATOMOXETINE (Strattera)
PUBMED GOOGLE SEARCH ENGINE HITS GOOGLE AD
ARTICLES NEWS ITEMS (WORDTRACKER) ($/CLICK)
3 WKS AGO 0 22 474 $0.16
2 WKS AGO 0 49 593 $0.16
LAST WEEK 1 47 776 $0.16
THIS WEEK 5 51 1013 $0.14
1: [No authors listed]Atomoxetine (Strattera) for ADHD.Med Lett Drugs Ther. 2003 Feb 3;45(1149):11-12. [PubMed]
2: Wernicke JF, Kratochvil CJ.
Safety profile of atomoxetine in the treatment of children and adolescents with ADHD.J Clin Psychiatry. 2002;63 Suppl 12:50-5. [PubMed]
3: Allen AJ, Michelson D.
Drug development process for a product with a primary pediatric indication.J Clin Psychiatry. 2002;63 Suppl 12:44-9. [PubMed]
4: Spencer TJ, Biederman J, Wilens TE, Faraone SV.
Novel treatments for attention-deficit/hyperactivity disorder in children.J Clin Psychiatry. 2002;63 Suppl 12:16-22. [PubMed]
5: Spencer TJ, Biederman J, Wilens TE, Faraone SV.
Overview and neurobiology of attention-deficit/hyperactivity disorder.J Clin Psychiatry. 2002;63 Suppl 12:3-9. [PubMed]
BUPROPION (Wellbutrin, Wellbutrin SR, generic)
PUBMED GOOGLE SEARCH ENGINE HITS GOOGLE AD
ARTICLES NEWS ITEMS (WORDTRACKER) ($/CLICK)
3 WKS AGO 2 40 5697 $1.75
2 WKS AGO 4 24 5656 $1.61
LAST WEEK 5 23 5588 $1.50
THIS WEEK 1 36 5547 $1.71
1: Spencer TJ, Biederman J, Wilens TE, Faraone SV.Novel treatments for attention-deficit/hyperactivity disorder in children.
J Clin Psychiatry. 2002;63 Suppl 12:16-22. [PubMed]
CITALOPRAM (Celexa)
PUBMED GOOGLE SEARCH ENGINE HITS GOOGLE AD
ARTICLES NEWS ITEMS (WORDTRACKER) ($/CLICK)
3 WKS AGO 1 21 5502 $1.05
2 WKS AGO 1 21 5187 $0.96
LAST WEEK 4 14 5015 $0.81
THIS WEEK 1 18 4818 $0.70
1: Eichhammer P, Langguth B, Wiegand R, Kharraz A, Frick U, Hajak G.Allelic variation in the serotonin transporter promoter affects neuromodulatory effects of a selective serotonin transporter reuptake inhibitor (SSRI).
Psychopharmacology (Berl). 2003 Feb 1 [epub ahead of print] [PubMed]
DULOXETINE (Cymbalta) (not yet released)
PUBMED GOOGLE SEARCH ENGINE HITS GOOGLE AD
ARTICLES NEWS ITEMS (WORDTRACKER) ($/CLICK)
3 WKS AGO 1 20 101 $0.05
2 WKS AGO 0 30 106 $0.05
LAST WEEK 1 30 105 $0.05
THIS WEEK 0 32 109 $0.05
ESCITALOPRAM (Lexapro)
PUBMED GOOGLE SEARCH ENGINE HITS GOOGLE AD
ARTICLES NEWS ITEMS (WORDTRACKER) ($/CLICK)
3 WKS AGO 4 15 6902 $0.42
2 WKS AGO 1 15 7203 $0.16
LAST WEEK 0 10 7519 $0.13
THIS WEEK 0 14 7754 $0.15
FLUOXETINE (Prozac, Prozac Weekly, Sarafem, generic)
PUBMED GOOGLE SEARCH ENGINE HITS GOOGLE AD
ARTICLES NEWS ITEMS (WORDTRACKER) ($/CLICK)
3 WKS AGO 7 407 3535 $2.64
2 WKS AGO 9 479 3503 $3.08
LAST WEEK 4 355 3460 $3.00
THIS WEEK 8 374 3429 $3.22
1: Pinna G, Dong E, Matsumoto K, Costa E, Guidotti A.In socially isolated mice, the reversal of brain allopregnanolone down-regulation mediates the anti-aggressive action of fluoxetine.
Proc Natl Acad Sci U S A. 2003 Feb 5 [epub ahead of print] [PubMed]
4: Mendes-Da-Silva C, Souza SL, Barreto-Medeiros JM, Freitas-Silva SR, Antunes DE, Cunha AD, Ribas VR, Fran a MF, Nogueira MI, Manh es-De-Castro R.
Neonatal treatment with fluoxetine reduces depressive behavior induced by forced swim in adult rats.
Arq Neuropsiquiatr. 2002 Dec;60(4):928-31. [PubMed]
7: Elena Castro M, Diaz A, del Olmo E, Pazos A.
Chronic fluoxetine induces opposite changes in G protein coupling at pre and postsynaptic 5-HT(1A) receptors in rat brain.
Neuropharmacology. 2003 Jan;44(1):93-101. [PubMed]
FLUVOXAMINE (Luvox, generic)
PUBMED GOOGLE SEARCH ENGINE HITS GOOGLE AD
ARTICLES NEWS ITEMS (WORDTRACKER) ($/CLICK)
3 WKS AGO 0 5 549 $0.08
2 WKS AGO 1 6 537 $0.08
LAST WEEK 1 4 519 $0.07
THIS WEEK 1 29 486 $0.08
1: Horiuchi H, Ogata T, Morino T, Takeba J, Yamamoto H.Serotonergic signaling inhibits hyperalgesia induced by spinal cord damage.
Brain Res. 2003 Feb 14;963(1-2):312-20. [PubMed]
MIRTAZAPINE (Remeron, Remeron Soltabs, generic)
PUBMED GOOGLE SEARCH ENGINE HITS GOOGLE AD
ARTICLES NEWS ITEMS (WORDTRACKER) ($/CLICK)
3 WKS AGO 2 5 1831 $0.12
2 WKS AGO 0 9 1612 $0.10
LAST WEEK 4 11 1593 $0.06
THIS WEEK 3 13 1593 $0.12
1: Schittecatte M, Dumont F, Machowski R, Cornil C, Lavergne F, Wilmotte J.Effects of mirtazapine on sleep polygraphic variables in major depression.
Neuropsychobiology. 2002;46(4):197-201. [PubMed]
2: Van Gool AR, Bannink M, Stronks DL, Vos MS.
Re. Mirtazapine in cancer patients.
J Pain Symptom Manage. 2003 Jan;25(1):7-8. No abstract available. [PubMed]
3: Teive HA, Quadros Ad A, Barros FC, Werneck LC.
[Worsening of autosomal dominant restless legs syndrome after use of mirtazapine: case report]
Arq Neuropsiquiatr. 2002 Dec;60(4):1025-9. Portuguese. [PubMed]
NEFAZODONE (Serzone, generic)
PUBMED GOOGLE SEARCH ENGINE HITS GOOGLE AD
ARTICLES NEWS ITEMS (WORDTRACKER) ($/CLICK)
3 WKS AGO 0 22 754 $4.19
2 WKS AGO 1 21 753 $3.84
LAST WEEK 0 18 736 $4.22
THIS WEEK 1 5 710 $1.52
1: Grunze H, Marcuse A, Scharer LO, Born C, Walden J.Nefazodone in Psychotic Unipolar and Bipolar Depression: A Retrospective Chart Analysis and Open Prospective Study on Its Efficacy and Safety versus Combined Treatment with Amitriptyline and Haloperidol.
Neuropsychobiology. 2002;46 Suppl 1:31-5. [PubMed]
PAROXETINE (Paxil, Paxil CR)
PUBMED GOOGLE SEARCH ENGINE HITS GOOGLE AD
ARTICLES NEWS ITEMS (WORDTRACKER) ($/CLICK)
3 WKS AGO 2 239 7765 $1.45
2 WKS AGO 5 258 7419 $1.72
LAST WEEK 4 145 7272 $1.41
THIS WEEK 3 184 7170 $0.67
1: Rickels K, Rynn M.Pharmacotherapy of generalized anxiety disorder.
J Clin Psychiatry. 2002;63 Suppl 14:9-16. [PubMed]
2: Chen J, Mabjeesh NJ, Matzkin H, Greenstein A.
Efficacy of sildenafil as adjuvant therapy to selective serotonin reuptake inhibitor in alleviating premature ejaculation.
Urology. 2003 Jan;61(1):197-200. [PubMed]
SERTRALINE (Zoloft)
PUBMED GOOGLE SEARCH ENGINE HITS GOOGLE AD
ARTICLES NEWS ITEMS (WORDTRACKER) ($/CLICK)
3 WKS AGO 1 50 5582 $3.21
2 WKS AGO 2 82 5528 $1.44
LAST WEEK 3 82 5478 $1.22
THIS WEEK 3 85 5443 $1.15
1: Devanand DP, Pelton GH, Marston K, Camacho Y, Roose SP, Stern Y, Sackeim HA.Sertraline treatment of elderly patients with depression and cognitive impairment.
Int J Geriatr Psychiatry. 2003 Feb;18(2):123-30. [PubMed]
2: Rickels K, Rynn M.
Pharmacotherapy of generalized anxiety disorder.
J Clin Psychiatry. 2002;63 Suppl 14:9-16. [PubMed]
3: Palmer TR.
Sertraline and vaginal bleeding- a possible association?
J Am Geriatr Soc. 2003 Feb;51(2):279. No abstract available. [PubMed]
VENLAFAXINE (Effexor, Effexor XR)
PUBMED GOOGLE SEARCH ENGINE HITS GOOGLE AD
ARTICLES NEWS ITEMS (WORDTRACKER) ($/CLICK)
3 WKS AGO 1 5 5446 $3.28
2 WKS AGO 0 5 5441 $3.91
LAST WEEK 9 61 5382 $3.97
THIS WEEK 2 64 5358 $0.23
1: Davies J, Lloyd KR, Jones IK, Barnes A, Pilowsky LS.Changes in regional cerebral blood flow with venlafaxine in the treatment of major depression.
Am J Psychiatry. 2003 Feb;160(2):374-6. [PubMed]
2: Rickels K, Rynn M.
Pharmacotherapy of generalized anxiety disorder.
J Clin Psychiatry. 2002;63 Suppl 14:9-16. [PubMed]
Google News Items indicate how many news articles are listed each week in the Google News site. If you don't know about this site, you should. It tracks 4000 news publications and websites for the past month. That means that the same articles will be in the list for 4-5 weeks, before they drop off. The PsychopharmINFO website has links to current and prior weeks' news searches. Many financial news articles are often listed because they mention a company's drug. If you see a spike in news articles, it can be interesting to see what all the hubbub is about.
Search Engine Hits lists the number of times per day that the brand name medication is searched in Wordtracker. Wordtracker accumulates this info from several different search engines, generating data on over 350 million searches. It is interesting to see which drugs are generating interest. FOr example, I find it very surprising that only five months after Lexapro's launch that it receives the highest number of search hits of all the antidepressants. It is also generating a large amount of hits on PsychopharmINFO.com. Also, the hits keep increasing each week. We'll see where it plateaus.
Finally, Google Ads are more interesting to marketing types. When you run a Google search, you see ads on the right. Each click on an ad costs the company a certain amount of money. The advertising companies tell Google the most it is willing to pay per click, and the most amount of money it is willing to pay per day. The prices in the tables indicate the cost per click if one sets a maximum of $5.00/click. It is another indication of interest level for the various medications. The big advertisers seem to be online pharmacies and lawyers' offices (look at Serzone; the high cost is due to attorneys looking for liver injury cases).
The PPI Index is a measure of the relative interest (search hits) and newsworthiness (Google News) of all the medications listed here. As the number of hits and news articles increase, the PPI index also increases. It's really just a catchy number to associate with the Newsletter, but may turn out to be interesting. We'll see.
So that's what the numbers are all about. The "Top 10" lists at the left tell you at a glance where the different drugs stand. As I later add other psychopharm drug classes, we'll see a greater mix of medication types here. Let me know how useful you find these statistics.
- Strattera results
- A number of studies came out this week, focussing on efficacy and safety results for atomoxetine, the new selective norepinephrine reuptake inhibitor (SNRI) which is indicated for ADHD. Lilly's marketing is emphasizing the fact that it is a nonstimulant, hoping that the stigma against amphetamine-like drugs will boost it's marketshare. So far, the results do look encouraging. We should expect that many psychopharmacologists will be using it as a possibly safer augmentation strategy than the other SNRI, desipramine/Norpramin. Another article reviews ADHD treatments, including Wellbutrin SR.
- Genes affect response to SSRIs
- This is worth noting. People with a particular genetic variation in their serotonin reuptake molecule have an enhanced response to the SSRI citalopram than those who lack this variation. This may partly explain why some do better than others with a given medication.
- Neonatal SSRI exposure may reduce adult depression
- This is an intriguing article. Of course it is in rats, but it suggests that exposure to SSRIs during brain development may reduce "depressive behavior" when the rats grow up. The "forced swim test" is where you place an animal in a pool of water where it can't escape, so it just treads water. The less it treads water, the more of depressive response there is.
- Brain imaging of antidepressant response
- There are only seven patients, but the results show changes in blood flow to the thalamus and other areas which correlate with response to venlafaxine. Look at the website in the Recent News Items section for a link to a movie of these changes.
Selected letters to the editor will be published here. Selection factors include conciseness, broad appeal, and originality. Name will be included unless signed "Anonymous". Comments, questions, and observations on research articles, news items, top 10 lists, surveys, and other letters are preferred. Letters may be edited for clarity and brevity.
Send letters to: editor@psychopharminfo.com