drdaviss@psychopharminfo.com
www.psychopharmINFO.com
Newsletter
Number 3
Monday, February 17, 2003
PPI Index: *89.6 (+0.1%)
Copyright 2003 by Steven R. Daviss
Hi, folks. I think I've got the spacing right on the newsletter so that it all fits without scrolling left and right. Your screen resolution should be set to 800x600 or higher. This should also allow you to print in portrait, rather than landscape, mode. You may still want to reduce the "Text size" in the VIEW menu to get more on a page. • • • The monthly website is now up to date for January, but of course, Newsletter subscribers are getting their up-to-date information every week. We don't have enough to start our subscribers-only discussion list yet, but I'll keep you posted. If each of you could get 3 or 4 people to subscribe, there would be enough of a core group to make it work. I have the software picked out: it is Movable Type. Articles of interest can be discussed in detail, allowing for a more educational forum. • • • This will likely be the last newsletter to get posted to the website. The rest will be email only. If you miss a copy, let me know and I'll shoot another one out to you. =Steve.
(by number of hits; (#)=position last week)
Hits #
1. Prozac 318 (1)
2. Paxil 242 (2)
3. Effexor 91 (4)
4. Zoloft 70 (3)
5. Wellbutrin 44 (6)
6. Strattera 38 (5)
7. Remeron 24 (9)
8. Celexa 17 (8)
9. Cymbalta 16 (7)
10. Serzone 4 (10)
TOP 10 SEARCHES FOR ANTIDEPRESSANTS
(by search hits; %=change from last week, as per WordTracker)
Hits %
1. Lexapro 7899 +2
2. Paxil 7100 -1
3. Wellbutrin 5514 -1
4. Zoloft 5487 +1
5. Effexor 5280 -2
6. Celexa 4656 -3
7. Prozac 3405 -1
8. Remeron 1605 +1
9. Strattera 1247 +23
10. Serzone 657 -8
-
SIDE EFFECTS & INTERACTIONS
- • Sexual
- -citalopram
- • Numbness
- -paroxetine
- • Review
- -bupropion
- • Interactions
- -fluoxetine- haloperidol/Haldol
- -fluvoxamine- haloperidol/Haldol
- -nefazodone- haloperidol/Haldol
Go To: | CELEXA | CYMBALTA | EFFEXOR | LEXAPRO | LUVOX | PAXIL | PROZAC | REMERON | SARAFEM | SERZONE | STRATTERA | WELLBUTRIN | ZOLOFT | ZYBAN
ATOMOXETINE (Strattera)
GOOGLE SEARCH
PUBMED NEWS ENGINE HITS GOOGLE AD
ARTICLES ITEMS (WORDTRACKER) ($/CLICK)
3 WKS AGO 0 49 593 $0.16
2 WKS AGO 1 47 776 $0.16
LAST WEEK 5 51 1013 $0.14
THIS WEEK 0 38 1247 $0.06
None.
BUPROPION (Wellbutrin, Wellbutrin SR, generic)
GOOGLE SEARCH
PUBMED NEWS ENGINE HITS GOOGLE AD
ARTICLES ITEMS (WORDTRACKER) ($/CLICK)
3 WKS AGO 4 24 5656 $1.61
2 WKS AGO 5 23 5588 $1.50
LAST WEEK 1 36 5547 $1.71
THIS WEEK 3 44 5514 $1.52
Vaillancourt R, Wagenaar H, Fisher C, Conway RD, Plemel J.A retrospective survey of the use of bupropion slow release by members of the Canadian Armed Forces.
Can J Clin Pharmacol. 2002 Winter;9(4):205-13. [PubMed]
Curry SJ, Ludman EJ, McClure J.
Self-administered treatment for smoking cessation.
J Clin Psychol. 2003 Mar;59(3):305-19. [PubMed]
CITALOPRAM (Celexa)
GOOGLE SEARCH
PUBMED NEWS ENGINE HITS GOOGLE AD
ARTICLES ITEMS (WORDTRACKER) ($/CLICK)
3 WKS AGO 1 21 5187 $0.96
2 WKS AGO 4 14 5015 $0.81
LAST WEEK 1 18 4818 $0.70
THIS WEEK 7 17 4656 $0.21
Atmaca M, Kuloglu M, Tezcan E, Ustundag B, Semercioz A.Serum leptin levels in patients with premature ejaculation before and after citalopram treatment.
BJU Int. 2003 Feb;91(3):252-4. [PubMed]
Varty GB, Cohen-Williams ME, Hunter JC.
The antidepressant-like effects of neurokinin NK1 receptor antagonists in a gerbil tail suspension test.
Behav Pharmacol. 2003 Feb;14(1):87-95. [PubMed]
Anderer P, Saletu B, Semlitsch HV, Pascual-Marqui RD.
Perceptual and cognitive event-related potentials in neuropsychopharmacology: methodological aspects and clinical applications (pharmaco-ERP topography and tomography).
Methods Find Exp Clin Pharmacol. 2002;24 Suppl C:121-37. [PubMed]
Saletu B, Anderer P, Saletu-Zyhlarz GM, Arnold O, Pascual-Marqui RD.
Classification and evaluation of the pharmacodynamics of psychotropic drugs by single-lead pharmaco-EEG, EEG mapping and tomography (LORETA).
Methods Find Exp Clin Pharmacol. 2002;24 Suppl C:97-120. [PubMed]
Anderer P, Saletu B, Semlitsch HV, Pascual-Marqui RD.
Structural and energetic processes related to P300: LORETA findings in depression and effects of antidepressant drugs.
Methods Find Exp Clin Pharmacol. 2002;24 Suppl D:85-91.[PubMed]
DULOXETINE (Cymbalta) (not yet released)
GOOGLE SEARCH
PUBMED NEWS ENGINE HITS GOOGLE AD
ARTICLES ITEMS (WORDTRACKER) ($/CLICK)
3 WKS AGO 0 30 106 $0.05
2 WKS AGO 1 30 105 $0.05
LAST WEEK 0 32 109 $0.05
THIS WEEK 0 16 117 $0.05
None.
ESCITALOPRAM (Lexapro)
GOOGLE SEARCH
PUBMED NEWS ENGINE HITS GOOGLE AD
ARTICLES ITEMS (WORDTRACKER) ($/CLICK)
3 WKS AGO 1 15 7203 $0.16
2 WKS AGO 0 10 7519 $0.13
LAST WEEK 0 14 7754 $0.15
THIS WEEK 0 6 7899 $0.13
None.
FLUOXETINE (Prozac, Prozac Weekly, Sarafem, generic)
GOOGLE SEARCH
PUBMED NEWS ENGINE HITS GOOGLE AD
ARTICLES ITEMS (WORDTRACKER) ($/CLICK)
3 WKS AGO 9 479 3503 $3.08
2 WKS AGO 4 355 3460 $3.00
LAST WEEK 8 374 3429 $3.22
THIS WEEK 5 318 3405 $3.18
Kalgutkar AS, Taylor TJ, Venkatakrishnan K, Isin EM.Assessment of the Contributions of CYP3A4 and CYP3A5 in the Metabolism of the Antipsychotic Agent Haloperidol to Its Potentially Neurotoxic Pyridinium Metabolite and Effect of Antidepressants on the Bioactivation Pathway.
Drug Metab Dispos. 2003 Mar 1;31(3):243-249. [PubMed]
Varty GB, Cohen-Williams ME, Hunter JC.
The antidepressant-like effects of neurokinin NK1 receptor antagonists in a gerbil tail suspension test.
Behav Pharmacol. 2003 Feb;14(1):87-95. [PubMed]
FLUVOXAMINE (Luvox, generic)
GOOGLE SEARCH
PUBMED NEWS ENGINE HITS GOOGLE AD
ARTICLES ITEMS (WORDTRACKER) ($/CLICK)
3 WKS AGO 1 6 537 $0.08
2 WKS AGO 1 4 519 $0.07
LAST WEEK 1 29 486 $0.08
THIS WEEK 1 29 480 $0.15
Kalgutkar AS, Taylor TJ, Venkatakrishnan K, Isin EM.Assessment of the Contributions of CYP3A4 and CYP3A5 in the Metabolism of the Antipsychotic Agent Haloperidol to Its Potentially Neurotoxic Pyridinium Metabolite and Effect of Antidepressants on the Bioactivation Pathway.
Drug Metab Dispos. 2003 Mar 1;31(3):243-249. [PubMed]
MIRTAZAPINE (Remeron, Remeron Soltabs, generic)
GOOGLE SEARCH
PUBMED NEWS ENGINE HITS GOOGLE AD
ARTICLES ITEMS (WORDTRACKER) ($/CLICK)
3 WKS AGO 0 9 1612 $0.10
2 WKS AGO 4 11 1593 $0.06
LAST WEEK 3 13 1593 $0.12
THIS WEEK 0 24 1605 $0.11
None.
NEFAZODONE (Serzone, generic)
GOOGLE SEARCH
PUBMED NEWS ENGINE HITS GOOGLE AD
ARTICLES ITEMS (WORDTRACKER) ($/CLICK)
3 WKS AGO 1 21 753 $3.84
2 WKS AGO 0 18 736 $4.22
LAST WEEK 1 5 710 $1.52
THIS WEEK 2 4 657 $3.58
Kalgutkar AS, Taylor TJ, Venkatakrishnan K, Isin EM.Assessment of the Contributions of CYP3A4 and CYP3A5 in the Metabolism of the Antipsychotic Agent Haloperidol to Its Potentially Neurotoxic Pyridinium Metabolite and Effect of Antidepressants on the Bioactivation Pathway.
Drug Metab Dispos. 2003 Mar 1;31(3):243-249. [PubMed]
Varty GB, Cohen-Williams ME, Hunter JC.
The antidepressant-like effects of neurokinin NK1 receptor antagonists in a gerbil tail suspension test.
Behav Pharmacol. 2003 Feb;14(1):87-95. [PubMed]
PAROXETINE (Paxil, Paxil CR)
GOOGLE SEARCH
PUBMED NEWS ENGINE HITS GOOGLE AD
ARTICLES ITEMS (WORDTRACKER) ($/CLICK)
3 WKS AGO 5 258 7419 $1.72
2 WKS AGO 4 145 7272 $1.41
LAST WEEK 3 184 7170 $0.67
THIS WEEK 6 242 7100 $0.70
Bertelsen KM, Venkatakrishnan K, Von Moltke LL, Obach RS, Greenblatt DJ.Apparent Mechanism-based Inhibition of Human CYP2D6 in Vitro by Paroxetine: Comparison with Fluoxetine and Quinidine.
Drug Metab Dispos. 2003 Mar 1;31(3):289-293. [PubMed]
Duggal HS.
Paroxetine-induced limb anesthesia.
Gen Hosp Psychiatry. 2003 Jan-Feb;25(1):51-2. No abstract available. [PubMed]
Sullivan MD, Katon WJ, Russo JE, Frank E, Barrett JE, Oxman TE, Williams JW Jr.
Patient beliefs predict response to paroxetine among primary care patients with dysthymia and minor depression.
J Am Board Fam Pract. 2003 Jan-Feb;16(1):22-31. [PubMed]
Fernandez F, Sarre S, Launay JM, Aguerre S, Guyonnet-Duperat V, Moisan MP, Ebinger G, Michotte Y, Mormede P, Chaouloff F.
Rat strain differences in peripheral and central serotonin transporter protein expression and function.
Eur J Neurosci. 2003 Feb;17(3):494-506. [PubMed]
Varty GB, Cohen-Williams ME, Hunter JC.
The antidepressant-like effects of neurokinin NK1 receptor antagonists in a gerbil tail suspension test.
Behav Pharmacol. 2003 Feb;14(1):87-95. [PubMed]
Melke J, Westberg L, Landen M, Sundblad C, Eriksson O, Baghei F, Rosmond R, Eriksson E, Ekman A.
Serotonin transporter gene polymorphisms and platelet [(3)H] paroxetine binding in premenstrual dysphoria.
Psychoneuroendocrinology. 2003 Apr;28(3):446-58. [PubMed]
SERTRALINE (Zoloft)
GOOGLE SEARCH
PUBMED NEWS ENGINE HITS GOOGLE AD
ARTICLES ITEMS (WORDTRACKER) ($/CLICK)
3 WKS AGO 2 82 5528 $1.44
2 WKS AGO 3 82 5478 $1.22
LAST WEEK 3 85 5443 $1.15
THIS WEEK 1 70 5487 $2.48
Varty GB, Cohen-Williams ME, Hunter JC.The antidepressant-like effects of neurokinin NK1 receptor antagonists in a gerbil tail suspension test.
Behav Pharmacol. 2003 Feb;14(1):87-95. [PubMed]
VENLAFAXINE (Effexor, Effexor XR)
GOOGLE SEARCH
PUBMED NEWS ENGINE HITS GOOGLE AD
ARTICLES ITEMS (WORDTRACKER) ($/CLICK)
3 WKS AGO 0 5 5441 $3.91
2 WKS AGO 9 61 5382 $3.97
LAST WEEK 2 64 5358 $0.23
THIS WEEK 2 91 5280 $0.17
Varty GB, Cohen-Williams ME, Hunter JC.The antidepressant-like effects of neurokinin NK1 receptor antagonists in a gerbil tail suspension test.
Behav Pharmacol. 2003 Feb;14(1):87-95. [PubMed]
• • • The interest in Strattera continues to climb, while Lexapro continues to be the number one searched antidepessant. Searches for Serzone continue to plummet, as folks decide the concerns about liver problems aren't worth it. Even the lawyers are losing interest, as Google has only 2 sponsored attorney links today (where it used to be 8 or more).
• • • Anxiety about terrorism is the latest national angst. Newsweek has a cover story on it this week.
• • • So far, the poll results (see below) indicate folks are primarily interested in side effects of medications. Once the meds are approved by the FDA, the assumption is that they work. Figuring out which ones have which side effects is a whole 'nother ball of wax. The package insert is a good starting point, but they list every side effect under the sun. The handout from the pharmacist is a briefer version. The PubMed articles can help, but aren't easily reviewed. What I have in mind is a side-by-side review of each of the medications, listed by side effect. Say, you don't want to take a chance of gaining weight. You look at the Weight Gain page and see the antidepressants listed in rank order of their risks of weight gain. Or, you want a med which makes you sleepy, so you look at the Sedation page for the drug which is most likely to make you sleepy. You get the idea. Let me know if you think this would be useful. The data would mostly come from package inserts and large studies, I think.
- NEW CLASS OF ANTIDEPRESSANT
- Neurokinin (NK1, also referred to as Substance P) antagonists are among the latest chemicals to be identified with antidepressant properties. They also reduce nausea and vomiting. The usual animal models (rats and mice) don't work as well for these drugs because their receptors are too different from ours. This paper shows that gerbils work well in this regard, showing that the NK1 antagonists acted just like a number of known antidepressants. You may want to keep tabs on some of these drugs, which include aprepitant (MK-869); L-742,694; L-733,060; CP-99,994; and CP-122,721.
- REVIEW OF ZYBAN SIDE EFFECTS
- Surveyed 357 members of the Canadian Armed Forces who took bupropion for smoking cessation. 47% were smoke-free for an average of 6 months. 70% reported side effects, and 12% saw a doctor due to side effects. The abstract does not list the types of side effects.
- CELEXA REDUCES LEPTIN IN SEXUAL DYSFUNCTION
- I don't really get this, but it has some implications for weight gain. Leptin is a hormone that has many functions, including weight regulation and sexual function. This study showed that men with premature ejaculation treated with citalopram had lower leptin levels than those on placebo.
- PAXIL RESPONSE TIED TO BELIEFS
- 333 people with dysthymia (chronic, minor depression) received either paroxetine or placebo. Folks who believed less in the biological basis of depression were more than 3 times more likely to achieve remission on Paxil than those who believed their depression was biological. These beliefs did not affect response to placebo.
Selected letters to the editor will be published here. Selection factors include conciseness, broad appeal, and originality. Name will be included unless signed "Anonymous". Comments, questions, and observations on research articles, news items, top 10 lists, surveys, and other letters are preferred. Letters may be edited for clarity and brevity.
Send letters to: editor@psychopharminfo.com